Regulation of apoptosis by Bcl-2 family proteins
نویسندگان
چکیده
منابع مشابه
Regulation of ceramide channels by Bcl-2 family proteins.
Mitochondrial outer membrane permeabilization to proteins, an irreversible step in apoptosis by which critical proteins are released, is tightly regulated by Bcl-2 family proteins. The exact nature of the release pathway is still undefined. Ceramide is an important sphingolipid, involved in various cellular processes including apoptosis. Here we describe the structural properties of ceramide ch...
متن کاملRegulation of apoptosis: involvement of Bcl-2-related proteins.
This article is a concise review of up-to-date information and recent discoveries concerning structure, site of action, tissue distribution, biological effects and molecular mechanisms of Bcl-2 family proteins. Particular attention has been focused on the physiological aspect of Bcl-2 protein function with emphasis on animal production and health. Bcl-2-related proteins are the principal regula...
متن کاملCeramide Channels and the Induction of Apoptosis: Structural Insights on Channel Formation and Regulation by Bcl-2 Family Proteins
Title of Dissertation: CERAMIDE CHANNELS AND THE INDUCTION OF APOPTOSIS: STRUCTURAL INSIGHTS ON CHANNEL FORMATION AND REGULATION BY BCL-2 FAMILY PROTEINS. Meenu Nadisha Perera, Doctor of Philosophy, 2012 Directed by: Professor Marco Colombini Department of Biology A critical event in apoptosis is the release of intermembrane space proteins from mitochondria following mitochondrial outer membran...
متن کاملXWH - 04 - 1 - 0182 TITLE : Regulation of calcium fluxes and apoptosis by BCL - 2 family proteins in prostate cancer cells
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines that induces apoptosis in some tumor cells but not in normal cells. Unfortunately, many human cancer cell lines are refractory to TRAIL-induced cell death, and the molecular mechanisms underlying resistance are unclear. Here we report that TRAIL resistance was reversed in...
متن کاملInduction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins.
OBJECTIVE The aims of the study were to evaluate the ability of metformin to induce apoptosis in epithelial ovarian cancer cell lines and to identify the pathways involved in this effect. METHODS After treatment with metformin and/or cisplatin, OVCAR-3 and OVCAR-4 cellular apoptosis was assessed by flow cytometry and caspase 3/7 activity. Cell cycle analysis was also performed by flow cytomet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2003
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2003.tb00225.x